$1.3 Million Grant for Research to Reduce Cardiac Injury 

Adenopaint, LLC of Atlanta, GA, in conjunction with LSU Health New Orleans Cardiovascular Center of Excellence, has been awarded an SBIR Phase II grant in the amount of $1.3 million over two years by the National Heart, Lung and Blood Institute. The funding will be used to study the company’s Adenowire, a novel guidewire coated with a drug which is released during percutaneous coronary intervention (PCI) to prevent and reverse vascular and cardiac tissue injury during PCI and therefore improve outcomes in cardiovascular diseases.

The grant will directly fund $735,000 to LSU Health New Orleans to study the efficacy of the Adenowire, a patented guidewire designed to produce immediate and continuous release of high dose adenosine locally to the injured tissue during coronary intervention procedures. Adenopaint’s Adenowire technology, the world’s first drug-eluting guidewire, could have a profound impact on millions of people suffering from coronary artery disease undergoing angioplasty each year. The newly funded research will investigate its effectiveness in reducing tissue injury in a model of acute myocardial infarction, or heart attack. A goal of this research is to move this promising new technology towards human clinical trials.

Adenopaint’s CEO Mervyn Forman, MD, PhD and LSU Health New Orleans Cardiovascular Center of Excellence Director David Lefer, PhD, are the grant’s principal investigators. They will work alongside LSU Health New Orleans Cardiovascular Center Translational Core Laboratory Director Traci Goodchild, PhD, to evaluate the effect of Adenowire to increase blood flow and reduce heart muscle damage in an experimental model of heart attack.  There is dire need to develop a safe device to reduce heart muscle damage and prevent heart failure in patients with acute heart attacks.

While at an early stage of overall development, the Adenowire is likely to provide a substantial impact in the treatment of tissue perfusion injury. A guidewire containing covalently bonded adenosine for controlled local delivery is innovative and if these studies are successful, likelihood of commercialization is high.

“This approach could potentially effect more than 1 million people worldwide yearly with better outcomes following acute myocardial infarction,” said Dr. David Lefer, Professor of Pharmacology and Director of the Cardiovascular Center of Excellence at LSU Health New Orleans School of Medicine.

 

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