Publications of Note

Congratulations to the following individuals for the publication of their work in respected journals from June 1 – July 31, 2018 as reported to The Pulse by individual departments:

Genetics

Matossian MD, Burks HE, Bowles AC, Elliott S, Hoang VT, Sabol RA, Pashos NC, O’Donnell B, Miller KS, Wahba BM, Bunnell BA, Moroz K, Zea AH, Jones SD, Ochoa AC, Al-Khami AA, Hossain F, Riker AI, Rhodes LV, Martin EC, Miele L, Burow ME, Collins-Burow BM. (2018) A novel patient-derived xenograft model for claudin-low triple-negative breast cancer. Breast Cancer Res Treat. Jun;169(2):381-390. doi: 10.1007/s10549-018-4685-2.

Halabi A, Fuselier KTB, Grabczyk E. GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one. Nucleic Acids Res. 2018 May 4;46(8):4022-4032. doi: 10.1093/nar/gky143.

Liu Y, Lusk CM, Cho MH, Silverman EK, Qiao D, Zhang R, Scheurer ME, Kheradmand F, Wheeler DA, Tsavachidis S, Armstrong G, Zhu D, Wistuba II, Chow CB, Behrens C, Pikielny CW, Neslund-Dudas C, Pinney SM, Anderson M, Kupert E, Bailey-Wilson J, Gaba C, Mandal D, You M, de Andrade M, Yang P, Field JK, Liloglou T, Davies M, Lissowska J, Swiatkowska B, Zaridze D, Mukeriya A, Janout V, Holcatova I, Mates D, Milosavljevic S, Scelo G, Brennan P, McKay J, Liu G, Hung RJ, Christiani DC, Schwartz AG, Amos CI, Spitz MR. Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer. J Thorac Oncol. 2018 Jul 4. pii: S1556-0864(18)30767-6. doi: 10.1016/j.jtho.2018.06.016.

Byun J, Schwartz AG, Lusk C, Wenzlaff AS, de Andrade M, Mandal D, Gaba C, Yang P, You M, Kupert EY, Anderson MW, Han Y, Li Y, Qian D, Stilp A, Laurie C, Nelson S, Zheng W, Hung RJ, Gaborieau V, Mckay J, Brennan P, Caporaso NE, Landi MT, Wu X, McLaughlin JR, Brhane Y, Bossé Y, Pinney SM, Bailey-Wilson JE, Amos CI. Genome-Wide Association Study of Familial Lung Cancer. Carcinogenesis. 2018 Jun 19. doi: 10.1093/carcin/bgy080.

 

Crabtree JS, Miele L. Breast Cancer Stem Cells. Biomedicines. 2018 Jul 17;6(3). pii: E77. doi: 10.3390/biomedicines6030077.

Kuhns KJ, Zhang G, Wang Z, Liu W. ARD1/NAA10 acetylation in prostate cancer. Exp Mol Med. 2018 Jul 27;50(7):89. doi: 10.1038/s12276-018-0107-0

Chen C, Breslin MB, Lan MS. Sonic hedgehog signaling pathway promotes INSM1 transcription factor in neuroendocrine lung cancer. Cell Signal. 2018 Jun;46:83-91. doi: 10.1016/j.cellsig.2018.02.014.

Microbiology, Immunology, and Parasitology:

Molina PE, Simon L, Amedee AM, Welsh DA, Ferguson TF. (2018) Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings. Alcohol Alcohol. Jul 1;53(4):439-447. doi: 10.1093/alcalc/agy016.

Kang X, Kirui A, Muszyński A, Widanage M, Chen A, Azadi P, Wang P, Mentink-Vigier F, Wang T. (2018) Molecular architecture of fungal cell walls revealed by Solid-State NMR. Nat Commun. Jul 16;9(1):2747. doi: 10.1038/s41467-018-05199-0.

Ibana JA, Sherchand SP, Fontanilla FL, aNagamatsu T, Schust DJ, Quayle AJ, Aiyar A. (2018) Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma. Sci Rep. May 31;8(1):8476. doi: 10.1038/s41598-018-26765-y.

Wen ZT, Scott-Anne K, Liao S, De A, Luo M, Kovacs C, Narvaez BS, Faustoferri RC, Yu Q, Taylor CM, Quivey RG. Deficiency of BrpA in Streptococcus mutans reduces virulence in rat caries model. (2018) Mol Oral Microbiol. Jun 11. doi: 10.1111/omi.12230. [Epub ahead of print]

Muzny CA, Blanchard E, Taylor CM, Aaron KJ, Talluri R, Griswold ME, Redden DT, Luo M, Welsh DA, Van Der Pol WJ, Lefkowitz EJ, Martin DH, Schwebke JR. Identification of Key Bacteria Involved in the Induction of Incident Bacterial Vaginosis: A Prospective Study. (2018) J Infect Dis. Aug 14;218(6):966-978. doi: 10.1093/infdis/jiy243.

Matossian MD, Burks HE, Bowles AC, Elliott S, Hoang VT, Sabol RA, Pashos NC, O’Donnell B, Miller KS, Wahba BM, Bunnell BA, Moroz K, Zea AH, Jones SD, Ochoa AC, Al-Khami AA, Hossain F, Riker AI, Rhodes LV, Martin EC, Miele L, Burow ME, Collins-Burow BM. (2018) A novel patient-derived xenograft model for claudin-low triple-negative breast cancer. Breast Cancer Res Treat. Jun;169(2):381-390. doi: 10.1007/s10549-018-4685-2.

Cameron JE, Rositch AF, Vielot NA, Mugo NR, Kwatampora JKL, Waweru W, Gilliland AE, Hagensee ME, Smith JS. (2018) Epstein-Barr virus, high-risk human papillomavirus and abnormal cervical cytology in a prospective cohort of African female sex workers. Sex Transm Dis. 45(10):666-672 doi: 10.1097/OLQ.0000000000000857.

Gao L, Wang Y, Hua Z, Liu E, Shen L. (2018) Potency of solithromycin against fast and slow growing chlamydial organisms. Antimicrob Agents Chemother. Jun 11. pii: AAC.00588-18. doi: 10.1128/AAC.00588-18. [Epub ahead of print]

Pediatrics

Dumas SA, Terrell IW, Gustafson M. Health and Social Needs of Young Mothers. MCN Am J Matern Child Nurs. 2018 May/Jun;43(3):146-152. doi: 10.1097/NMC.0000000000000427.

Ashoor IF, Dharnidharka VR. Non-immunologic allograft loss in pediatric kidney transplant recipients. Pediatr Nephrol. 2018 Feb 26 doi: 10.1007/s00467-018-3908-4. [Epub ahead of print]

Otolaryngology

Kane, AC, Walvekar, RR and Hotaling, JM. Transoral robotic resection of a retropharyngeal parathyroid adenoma: a case report. Journal of Robotic Surgery 2018 doi: 10.1007/s11701-018-0843-0. [Epub ahead of print]

 

 

 

 

 

 

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Upcoming Dean’s Seminars:

October 10

  • noon-1pm
  • CSRB 563
  • Dr. Jeffrey Carter

November 14

  • 11am-noon
  • CSRB 563
  • Dr. Lucio Miele

December 12

  • noon-1pm
  • CSRB 563
  • Dr. Patricia Molina

White Coat Ceremony

 The LSU Health New Orleans School of Medicine held its annual White Coat Ceremony on Saturday, September 22, 2018, at the Jung Hotel Grand Hall.  This year, 202 members of the LSU Health New Orleans Medical School Class of 2022 received white coats, a visible symbol of patient care. During the ceremony, students were “coated” in order of their mentoring house by faculty members chosen by each individual house.  The coaters for this year’s ceremony were:

  • Audubon House: Ted Weyand, Ph.D. and Grace Athas, Ph.D.
  • Carrollton House: Robin English, M.D. and Taniya De Silva, M.D.
  • Decatur House: Ann Tilton, M.D. and Lauren Nunez, M.D.
  • Esplanade House: Julio Figueroa, M.D. and Victoria Burke, M.D.
  • Magazine House: Robert Maupin, M.D. and Joy Sturtevant, Ph.D.
  • Napoleon House: Xiaolin Tian, Ph.D. and Kyle Fulton, M.D.
  • Rampart House: Andrew Hollenbach, Ph.D. and David Borne, M.D.
  • Tchoupitoulas: Jennifer Hart, M.D. and Lee Engel, M.D., Ph.D.

According to the Arnold P. Gold Foundation, the cloaking with the white coat—the mantle of the medical profession—is a hands-on experience that underscores the bonding process. The coat is placed on each student’s shoulders by individuals who believe in the students’ ability to carry on the noble tradition of doctoring. It is a personally delivered gift of faith, confidence and compassion.

Following the coating, the class recited its Oath of Ideals. Each class develops its own Oath of Ideals.  The White Coat Ceremony is a tradition begun at LSU Health New Orleans’ School of Medicine in 1997.

 

Words From the Library: Introducing Discovery/EDS Health!

Kathy Kerdolff, Librarian

Did you ever wish the Library had a quick way to search a bunch of stuff at one time? You can do so now with the unveiling of the Discovery/EDS Health tool! This new service allows you to search multiple databases and is another way to find many of the Library’s subscribed resources.

The Library’s home page has a new look with the Discovery tool’s search box:

library

From this box you can search everything that’s available, or just for articles, books, or journals. A keyword search will get you to a screen where you can start to explore all of the available resources.

If you’re familiar with other EBSCOhost databases such as CINAHL or Academic Search Complete, the presentation of the results and the options you have to refine your search should be familiar. You can also perform your search in PubMed, EMBASE, and ClinicalKey by clicking on the icons for each to the right of the screen.

One of the greatest benefits of the Discovery tool is that it brings together many databases, including MEDLINE, Scopus, and CINAHL, along with the majority of resources the Library subscribes to, such as books from AccessMedicine, journals from ScienceDirect, and items from the print collection, and puts them all in one place.

If you prefer to search other databases, those are still available, and the Discovery tool is meant to complement our current offerings.

If you are off-campus, you can search the Discovery service from the Library’s home page, but you may find that you are unable to get into everything that’s offered. As long as you see the yellow banner at the top, you’re looking at everything as a guest, and you will need to authenticate in order to get to any full-text content or to access all of the features of the tool.

In order to fully use the service, just click on the yellow banner at the top of the page. You will then be asked to enter your Library barcode and PIN through our EZproxy login service. More information and help about accessing Library resources when off-campus is available on the Library’s Databases page.

In the coming weeks we will have more posts that delve into the many features of this dynamic tool. There is a LibGuide available that walks through some of the basic features of the Discovery service, and Library staff always welcome your questions.

We hope you will find this new service useful and that it provides a way to get to more of the Library’s resources.

 

Russell Klein, M.D. – In Memorium

R. KleinOur LSU Health family has lost a valued colleague and friend with the passing of Dr. Russell Klein on September 2, 2018 as a result of complications of meningitis. Funeral services were held on Saturday, September 8, at Schoen’s Funeral Home on Canal Street in New Orleans.

Russell Charles Klein, MD was born on May 30, 1935 and was a native New Orleanian. He is survived by his wife of 43 years, Donna Guinn Klein, his brother Edward J. Klein, Jr., and his children Steven David Klein, Robin Irene Klein, and his beloved rescue dog, Jessie. He is also survived by his sister-in-law, Margaret Scott (Greg), loving nieces and nephews, and a multitude of friends and colleagues.

He was a graduate of Jesuit High School, Loyola University and received his medical degree from LSU School of Medicine in New Orleans in 1959. He did his residency training at Charity Hospital and completed a pulmonary fellowship at Harvard Medical School and the Massachusetts General Hospital in Boston. He served our country as a medical officer in the United States Army (Honorable Discharge) in Germany from 1961-63.

Dr. Klein joined the LSU School of Medicine faculty in 1967 and served in many roles, including Associate Dean of Alumni Affairs and Development, and retiring as Emeritus Professor in 2010. His distinguished career included many professional positions including Director of Respiratory Therapy at the Medical Intensive Care unit at Charity Hospital. He was active in organized medicine, serving in leadership roles in the Orleans Parish Medical Society and as President of the Louisiana State Medical Society. In 2009 the LSU Board of Supervisors on the recommendation of the Chancellor, named the Center for Advanced Practice Simulation Center at the School of Medicine the Russell C. Klein MD (’59) Center for Advanced Practice. Dr. Klein authored and co-authored more than 30 peer-reviewed publications, and in 2010 published “A History of the LSU School of Medicine in New Orleans.” He was actively involved in the Alpha Omega Alpha Medical Honor Society, the American College of Chest Physician and the Association of American Colleges Group on Institutional Advancement. Over his more than a half-century of service to his alma mater, Russell’s contributions to the School of Medicine were truly incalculable.

 

 

 

 

New Team Based Learning Classroom – Open for Business!

Andrew D. Hollenbach, Ph.D., Co-Director Basic Science Curriculum
Robin English, M.D., Assistant Dean of Undergraduate Medical Education

You’ve seen the construction, you’ve heard the noise, and your classes have probably been disrupted in the last year because of the construction.  However, all of the inconvenience from the construction was well worth it: the new School of Medicine Team Based Learning (TBL) classroom is open for business and being used to great success.

To better address the learning needs of our students, the Office of Medical Education along with course directors and other faculty are working hard to develop new active learning classroom sessions to facilitate delivery, retention, and synthesis of material.  These educational delivery modalities include team based learning, peer based learning, clinical case studies with discussion, and clicker question sessions, to name a few.

This classroom, which was specially designed to facilitate the implementation of these active learning sessions, is capable of accommodating all 200 students within a medical school class, enabling them to work simultaneously on problems in groups of 6 or 7.  Audiovisual equipment is state of the art; six large monitors allow the display of information to the entire classroom and each small group has a computer screen at their table with HDMI hook-ups allowing them to display information to their individual small group.  Faculty are capable of selecting a display from the small group to display to the entire class to allowing students to lead others through their thinking, among many other exceptional capabilities in the room.  This technology and environment allows our faculty to guide students through the cases, stopping to emphasize key concepts as needed.

We’re only beginning to make use of this room, but despite working through small bugs and glitches, faculty and students alike are embracing this room and excited about using it to its full capability.

 

 

Ochnser Hosts LGBT Healthcare Summit

Our colleagues at Ochsner Hospital will be hosting an LGBTQ Healthcare Summit on Saturday, October 6 from 12:00 – 5:00 PM.  Hosted by The Ochsner LGBTQ Resource Group and Ochsner PRIDE, the summit entitled “Living Well Together”, aims to provide LGBTQ people living in Southeast Louisiana comprehensive information about health and wellness through lively panel discussions and engaging audience Q&A sessions.  The event is meant to go beyond the routinely discussed health struggles of the LGBTQ community in the South and to encourage participants to connect with local organizations that promote LGBTQ health and wellness.

LGBT Health SymposiumThe summit is free and open to the public with a light dinner buffet provided.  There is limited seating for the panel discussions, so free registration is required in order to reserve a seat.  More information and registration can be found at the following link:

https://www.eventbrite.com/e/lgbtq-health-summit-living-well-together-tickets-49823293813?ref=enivtefor001&invite=MTUwMTQ3MjYvY2hyaXN0b3BoZXIuZ2FybmV0dEBvY2hzbmVyLm9yZy8x%0A&utm_source=eb_email&utm_medium=email&utm_campaign=inviteformalv2&utm_term=eventpage

The International Students Association

Aratrika Saha
ISA President

Starting a new phase of life can be a very daunting experience whether it’s graduate school, a new job, or moving to a new city, let alone moving to a new country. Nonetheless, when the final confirmation comes in, we brace ourselves and dive headfirst into unknown waters. The journey we undertake is quite harrowing, both physically and mentally. We are forced to deal with legalities and formalities that seem never-ending. By the time we land on foreign soil, we feel that we’ve become quite adept at handling the unknown and are ready for all the curveballs life throws at us. Unfortunately, that is not true.

Habituating oneself to a new culture is exceedingly demanding, and often in this process of adaptation, we misplace our own identity. We strive to build a home for ourselves while navigating unfamiliar territories and soon find ourselves unable to lift the weight of our responsibilities. Even though eventually we do establish ourselves, it takes time and a lot of effort.

The International Students Association (ISA) is a newly formed association whose goal is to help international personnel establish themselves and solidify their identity in this kaleidoscope of cultures.  The foundation for the ISA was laid 2 years ago when our founding president decided to form this association and began the official paperwork to bring ISA into existence under the guidance of our faculty advisors.

Our mission is the Empowerment, Development, and Exchange of International personnel along with the Integration of knowledge and information about international culture and travel into LSUHSC.  Our vision encompasses the comfortable transition of all international personnel from their respective home countries to New Orleans, coordinate pre-arrival and post-arrival milestones, improve the participation of international personnel in schoolwide and citywide events, and coordinate meets with international Alumni.

We will be having several events and fundraisers throughout the year. We hope to establish a speaker series with speakers addressing different topics like policies and laws concerning international personnel, international travel, culture, and working abroad, to name a few. Fundraisers are going to celebrate a variety of international festivals. It is our objective to host 3 to 4 fundraisers each year, each celebrating a different festival. Our upcoming fundraiser in November is going to celebrate the Festival of Lights, which is celebrated across different cultures and is known by many names like Deepavali in India, Fête des lumières in France, and Spring Lantern Festival in China.

Establishing ties with the international community in other universities and creating an international alumni database is high among our list of priorities. We aspire to establish a network for international personnel that will amount to a substantial resource.

We invite everyone to join us in our endeavor to make LSUHSC a better place not just for the international community but for everyone, to help us bridge the cultural gap and to truly appreciate this fusion of cultures.

 

Join Up and Walk! AHA Heart Walk

This year, in contrast to years past, LSU Health Sciences Center aims to have a single team for the American Heart Association Heart Walk, which is a 1.8 mile walk scheduled for 8 am on November 17th at LaSalle Park in Metairie.  Cardiovascular disease is the number one killer of men and women in America and has a higher-than-average incidence in south Louisiana; each year, ~600,000 Americans die of heart disease, with an average of one death every 38 seconds.  LSUHSC’s Cardiovascular Center of Excellence is at the forefront of research and discovery of treatments for cardiac disease and is supported through grants from the American Heart Association, amongst others.

Our aim is to highlight the good work we do at LSUHSC for cardiovascular care.  Knowing that heart disease is something with which many of our colleagues will have personal or family experience, we are confident that a strong LSUHSC presence will underscore our passion and commitment to the care of patients with these diseases. Moreover, we believe that excellence in cardiac care is best achieved through a collaborative effort, requiring the dedication of members from all of our schools. We seek to mirror this interprofessional approach to patient care through a solitary, united team at this year’s event.

Please use the link below to sign up, and feel free to share this link with others in your professional and personal network to solicit team members.  No donation is necessary (or expected) but we are hoping to have a strong LSUHSC presence.

http://www2.heart.org/site/TR?fr_id=3688&pg=team&team_id=404496 . Once you are on the page, click Join this Team on the left.

Questions about the event can be directed to Drs. Bradley Spieler, Suresh Alahari, Dan Kapusta, or Zee Ali.

LSUHSC Bioinformatics and Genomics Program in the Cloud – No More Genomics Snail Mail 

Chindo Hicks, Ph.D. (Department of Genetics)

LSUHSC-SOM’s Bioinformatics and Genomics (BIG) Program, in partnership with University of Chicago’s Computational Institute and through a National Cancer Institute grant, have deployed the Globus platform. This new and advanced cloud-based computing platform supports the transfer, management and sharing of big and multi-omics data among investigators. LSUHSC investigators can now use this cloud-based platform to transfer and share big data and large-scale multi-platform and multi-omics data with their collaborating partners around the country and around the world.  The project is led jointly by Dr. Ian T. Foster (PI), Arthur Holly Compton Distinguished Service Professor of Computer Science and Director of the Data Science and Learning division at Argonne National Laboratory, the creator of the Globus platform; and Dr. Chindo Hicks, Professor of Genetics and Director of LSUHSC-SOM’s BIG Program (PI for the LSUHSC site).

The platform includes Globus Genomics, a cloud-based, elastic system for genomics analysis in the cloud. The platform addresses the needs of researchers, allows management of big data, and provides additional computation resources by providing frictionless access to advanced scientific computing capabilities and an easy way to deliver these capabilities to a broad user base through data sharing.

Whether the genotyping or sequencing is done at campus core facilities or off-site at an external vendor, for example at the Broad Institute in Boston or the HudsonAlpha Institute of Biotechnology in Alabama, moving hundreds of Terabytes of data over an FTP connection or by sending hard drives through the mail by FedEx can be a slow, error-prone process and can compromise data security. The Globus platform allows for the rapid transfer of dozens of exome sequences to BIG’s Bioinformatics and Computational Genomics laboratory. Instead of sending hard drives, it’s now easier for researchers at LSUHSC to just get data transferred electronically. Therefore, “no more genomics snail mail for LSUHSC investigators and cooperating partners.

The BIG and Globus teams are currently working on linking LSUHSC high-performance computing platforms with the Amazon, Google, IBM and the Microsoft Azure cloud computing platforms using the Globus platform.  This will allow us to leverage LSUHSC-SOM resources and to be more competitive as we develop the LSUHSC genomics research enterprise and reposition our cancer center to achieve comprehensive designation from the NCI. In addition to deploying the Globus platform and the data delivery, sharing and analysis pipeline, the BIG and Globus teams are conducting training workshop seminars for LSUHSC investigators.

Investigators who are interesting in learning more about the platform should contact Dr. Chindo Hicks, Globus PI for the LSUHSC Site at chick3@lsuhsc.edu or the LSUHSC Bioinformatics team at https://www.medschool.lsuhsc.edu/bioinformatics/