Agili-C IDE Pivotal Study

Leslie Capo
Director of Information Services

CartiHeal, developer of Agili-C, a proprietary implant for the treatment of joint surface lesions, and two LSU Health New Orleans orthopaedic surgeons announced today the successful enrollment of the first two US patients in the Agili-C IDE pivotal study. The first two cases in the United States were performed by Principle Investigator Dr. Vinod Dasa, Associate Professor and Director of Orthopaedic Research, and Dr. Michael Hartman, Associate Professor of Orthopaedic Surgery at LSU Health New Orleans School of Medicine, on August 14, 2018.

The first patient who was randomized to receive an Agili-C implant in the US is a 53-year-old male.  He suffered from a chronic painful cartilage lesion in the trochlea’s center and received a single implant in a mini-arthrotomy approach.

“Currently we lack good treatment options for patients who experience persistent knee pain due to cartilage problems and are too young for knee replacement” said Dr. Dasa. “The Agili-C implantation was smooth without complications. We plan to enroll more patients in the upcoming weeks and hope that this IDE trial finds that the Agili-C implant alleviates pain in these patients, allowing them to return to an active lifestyle.”

In Europe and Israel, 80 patients have already been enrolled and treated in the study, which will include a minimum of 250 patients in US and OUS centers, aiming for an FDA PMA application. The trial’s objective is to demonstrate the superiority of the Agili-C implant over surgical standard of care (microfracture and debridement) for the treatment of cartilage or osteochondral defects, in both arthritic knees and knees without degenerative changes.

Nir Altschuler, Cartiheal’s founder & CEO said, “We would like to congratulate Dr. Dasa and Dr. Hartman for enrolling the first two US patients. This is a significant milestone for our company and for our study. We are very pleased with the enrollment rate to date, and plan to open more US sites in the near future.”

CartiHeal’s cell-free, off-the-shelf implant is CE marked for use in cartilage and osteochondral defects. Agili-C was implanted in a series of trials conducted in leading centers in Europe and Israel, in over 400 patients with cartilage lesions in the knee, ankle and great toe. In these trials, the implant was used to treat a broad spectrum of cartilage lesions, from single focal lesions to multiple and large defects in patients suffering from osteoarthritis.

For more information about the Agili-C IDE study at LSU Health New Orleans, contact Cara Rowe, MSW, CCRP, Orthopaedics Clinical Research Coordinator at 504-568-4640.

 

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Lucio Miele Invited to Present Keynote Speech 

mieleLucio Miele, M.D., Ph.D., Department Head of Genetics was invited to present the keynote address at the Second International Conference or Oncology and Radiology, held in Rome, Italy, September 17 – 19, 2018.  The title of his talk was “Opportunities and Challenges in Cancer Precision Medicine.”

 

Dr. Angela McLean Featured in New Orleans Magazine 

Yet another of LSU SOM exceptional clinicians and educators is featured in New Orleans magazine.  Angela McLean, M.D., Professor in the Department of Medicine and Co-Director of the Clinical Curriculum in the Office of Undergraduate Medical Education was highlighted in the August issue of New Orleans magazine for her savvy handling of a difficult patient case.  You can read the entire story here.

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Tsien Named New Orleans Magazine Top Female Achiever 

FernTsien.jpgEach year New Orleans Magazine profiles women from the community who continue to make a difference.  This year, Fern Tsien, Ph.D. (Department of Genetics) was honored to be named one of these women.   

Dr. Tsien received this honor partly because of her research into the genetic causes of hearing loss in the Louisiana Acadians and Mexican Mayan populations.  Her research has been presented to local, national and international audiences and may ultimately lead to unlocking new diagnostic tests or therapies for deafness caused by genetic mutations.  

In addition to her research, Tsien provides extensive community outreach programs to regional schools.  She serves as the co-director of the Science Youth Initiative (SYI) program, which works to engage local elementary and high school students in the sciences. Enlisting the help of medical students and public health graduate students, SYI works with schools to reinforce lessons through hands-on experiments.  The SYI creates a wider exposure to science while raising standardized test scores in science.  

She also provides programs for middle and high school students where they are provided the chance to spend a day at LSU doing STEM experiments with academics.  The goal of SYI’s work is to create a pipeline for the third part of the program which includes paid, eight-week summer internships for high school students, many of whom advance to college and science or health-related careers. 

Congratulations Dr. Tsien! 

Patricia Molina Receives RSA Award 

Congratulations go out to Patricia Molina, M.D/Ph.D. (Department Chair, Physiology) for being awarded the 2018 Seixas Award from the Research Society for Alcohol (RSA).  Dr. Molina received this award for her dedicated service to the RSA, her history of outstanding research, her dedication to training young scientists, and her administrative excellence. 

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Lefer To Lead International Heart Research Society Section 

Leslie Capo, Director of Information Services 

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David Lefer, PhD, Director of LSU Health New Orleans’ Cardiovascular Center of Excellence, was inaugurated as President-Elect of the International Society of Heart Research – North American Section at its 37th Annual Conference in Halifax, Nova Scotia. He will serve a three-year term before assuming the presidency. 

 According to the Society, the mission of the International Society of Heart Research is to promote the discovery and dissemination of knowledge in the cardiovascular sciences on a worldwide basis through publications, congresses and other media. Membership has grown to include more than 3,000 members. The Society has seven sections – North American, Australasian, Chinese, European, Indian, Japanese and Latin American. 

 Dr. Lefer, who is also a professor of pharmacology, has been working in the fields of myocardial protection and coronary physiology for more than 20 years. He is an internationally recognized leader in understanding the role of nitric oxide and other nitrogen oxide-metabolites in ischemia-reperfusion injury to the heart. His laboratory was among the first to demonstrate the profound loss of endothelial cell-derived nitric oxide from the coronary circulation following coronary artery occlusion and reperfusion.  Lefer’s laboratory was the first to report on the potent cardioprotective actions of nitric oxide in acute myocardial infarction and congestive heart failure.  Several nitrite therapies are currently in clinical trials in the United States and Europe.  In 2005, Lefer’s laboratory began studying the potential cytoprotective actions of a second gaseous signaling molecule – hydrogen sulfide (H2S).  Lefer’s laboratory was also among the first to demonstrate that H2S helps prevent or limit damage in acute myocardial infarction and heart failure model systems. 

 

Medical Student Wins Research Day Award in Baton Rouge

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Congratulations go out to third year medical student Lauren Petit for winning best clinical research poster at LSU-Health Baton Rouge Regional Research day!  Lauren is presently performing third year clinical rotations in Baton Rouge.

Her poster is entitled “Clinical Impact of Shave Biopsy on Surgical Management of Cutaneous Melanoma” and was performed with John Lyons, M.D. in Surgical Oncology.

 

Dr. Moreno-Walton 1st Female Elected To Lead AAEM 

 Leslie Capo, Director of Information Services 

morenoLisa Moreno-Walton, MD, FAAEM, Professor of Emergency Medicine, Director of Research and Director of Diversity for the Section of Emergency Medicine at LSU Health New Orleans School of Medicine, has been elected President-Elect of the American Academy of Emergency Medicine (AAEM). She is the first female to hold the position. After serving a two-year term as President-Elect, Dr. Moreno will serve a two-year term as President of the specialty society of emergency medicine, followed by a two-year term as Past-President. 

Dr. Moreno also serves as Director of the Latino Scholars Program at LSU Health New Orleans School of Medicine and Director of Viral Testing at University Medical Center’s Department of Emergency Medicine.  

During her years serving on the AAEM Board of Directors, she has focused on the development of women and underrepresented minorities in leadership positions.  She holds degrees in Medicine and Clinical Research and is a National Institutes of Health Research Scholar.  She is the founder of the Academy for Diversity and Inclusion in Emergency Medicine (ADIEM), an academy of the Society of Academic Emergency Medicine (SAEM).  Her multiple awards include the SAEM Martin Leadership Award, Alpha Omega Alpha Medical Professionalism Award, Council of Residency Directors in Emergency Medicine Distinguished Educator Award, and the ADIEM Outstanding Academician Award. She also received the Association of American Medical Colleges (AAMC) Healthcare Executive Diversity & Inclusion Certificate. 

The recipient of many research grants, she has also given more than 500 academic presentations and authored or co-authored 45 publications, including 6 book chapters. She is the author of the textbook, “Diversity and Inclusion in Quality Patient Care.” Her second textbook is in press.  

Her research interests include HIV, violence prevention and treatment, diversity, and healthcare disparities.  She participates in LSU Health New Orleans Summer Research Program, mentoring college students who aspire to careers in medicine towards the completion of basic research projects.  She has mentored over 300 students, residents and junior faculty around the world towards successful careers in research and medicine.   

As a global health consultant and educator, she has served in more than 20 countries with a focus on the development of research and elimination of healthcare disparities for women, underrepresented minorities, and the under-resourced.  

 

LSU SOM Members Receive State Commendation 

Fern Tsien, Ph.D. (Department of Genetics)

April 17th, 2018 was LSU Day at the Louisiana Capitol, where two LSUHSC School of Medicine Initiatives were awarded:

The first was a Commendation by the Louisiana House of Representatives, sponsored by Rep. Julie Stokes for the “Southeast Partnership for Improving Research and Training (SPIRIT)” in cancer health disparities and the partnership’s receipt of a National Institutes of Health (NIH P20) Exploratory Center Grant. Accepting the Commendation were LSU President Dr. F. King Alexander, Genetics faculty member and SPIRIT Co-Investigator Dr. Fern Tsien, and Medical School Dean Dr. Steve Nelson.

The Louisiana Senate approved a Resolution for Science, Technology, Engineering, and Math (STEM) specifically to increase diversity. This resolution was sponsored by Senator Sharon Hewitt and was awarded to Dr. Robert Maupin, Dr. Paula Gregory, and Dr. Fern Tsien for the Science Youth Initiative (SYI), Tiger Cubs, New Orleans Schools Partnership program, Summer Science Program, Summer Health Professions Education Program (SHPEP), Research Experiences for Undergraduates (REU), Summer Research Internship Program, Post-Baccalaureate Research Education Program (PREP), and others. Accepting the Resolution were Dr. Allison Augustus-Wallace, Dr. Fern Tsien, Dr. Katrina Gleditsch, Ayesha Umrigar, and Martha Cuccia.